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Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps.

ABSTRACT:

Impact statement

The goal of this study was to determine the threshold for a critically sized, nonhealing muscle defect by characterizing key components in the balance between fibrosis and regeneration as a function of injury size in the mouse quadriceps. There is currently limited understanding of what leads to a critically sized muscle defect and which muscle regenerative components are functionally impaired. With the substantial increase in preclinical VML models as testbeds for tissue engineering therapeutics, defining the critical threshold for VML injuries will be instrumental in characterizing therapeutic efficacy and potential for subsequent translation.

SUBMITTER: Anderson SE

PROVIDER: S-EPMC6389771 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps.

Anderson Shannon E SE Han Woojin M WM Srinivasa Vunya V Mohiuddin Mahir M Ruehle Marissa A MA Moon June Young JY Shin Eunjung E San Emeterio Cheryl L CL Ogle Molly E ME Botchwey Edward A EA Willett Nick J NJ Jang Young C YC

Tissue engineering. Part C, Methods 20190201 2

<h4>Impact statement</h4>The goal of this study was to determine the threshold for a critically sized, nonhealing muscle defect by characterizing key components in the balance between fibrosis and regeneration as a function of injury size in the mouse quadriceps. There is currently limited understanding of what leads to a critically sized muscle defect and which muscle regenerative components are functionally impaired. With the substantial increase in preclinical VML models as testbeds for tissu ...[more]

PMID: 30648479

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