Ontology highlight
ABSTRACT:
SUBMITTER: Kano K
PROVIDER: S-EPMC6389983 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Kano Kuniyuki K Matsumoto Hirotaka H Inoue Asuka A Yukiura Hiroshi H Kanai Motomu M Chun Jerold J Ishii Satoshi S Shimizu Takao T Aoki Junken J
Scientific reports 20190225 1
Lysophosphatidic acid (LPA) is a blood-derived bioactive lipid with numerous biological activities exerted mainly through six defined G protein-coupled receptors (LPA<sub>1</sub>-LPA<sub>6</sub>). LPA was first identified as a vasoactive compound because it induced transient hypertension when injected intravenously in rodents. Here, we examined the molecular mechanism underlying the LPA-induced hypertensive response. The LPA-induced hypertensive response was significantly attenuated by pretreatm ...[more]