Ontology highlight
ABSTRACT:
SUBMITTER: Lee CW
PROVIDER: S-EPMC6390093 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Lee Chang Woo CW Park Sun-Ha SH Jeong Chang-Sook CS Cha Sun-Shin SS Park Hyun H Lee Jun Hyuck JH
Scientific reports 20190225 1
Cells regulate their intracellular mRNA levels by using specific ribonucleases. Oligoribonuclease (ORN) is a 3'-5' exoribonuclease for small RNA molecules, important in RNA degradation and re-utilisation. However, there is no structural information on the ligand-binding form of ORNs. In this study, the crystal structures of oligoribonuclease from Colwellia psychrerythraea strain 34H (CpsORN) were determined in four different forms: unliganded-structure, thymidine 5'-monophosphate p-nitrophenyl e ...[more]