Ontology highlight
ABSTRACT:
SUBMITTER: Nunez O
PROVIDER: S-EPMC6391077 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Bioorganic chemistry 20181025
Monomeric, dimeric, and trimeric derivatives of the triphenylmethane dye crystal violet (1a-1f) have been synthesized for the purpose of evaluating their affinity and sequence selectivity for duplex DNA. Competitive ethidum displacement assays indicate that 1a-1f have apparent association constants for CT DNA in the range of 1.80-16.2 × 10<sup>7</sup> M<sup>-1</sup> and binding site sizes of 10-14 bp. Viscosity experiments performed on ligand 1f confirmed that these dyes associate with duplex DN ...[more]