Ontology highlight
ABSTRACT:
SUBMITTER: Zhu S
PROVIDER: S-EPMC6391093 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhu Shouan S Zhu Jianxi J Zhen Gehua G Hu Yihe Y An Senbo S Li Yusheng Y Zheng Qin Q Chen Zhiyong Z Yang Ya Y Wan Mei M Skolasky Richard Leroy RL Cao Yong Y Wu Tianding T Gao Bo B Yang Mi M Gao Manman M Kuliwaba Julia J Ni Shuangfei S Wang Lei L Wu Chuanlong C Findlay David D Eltzschig Holger K HK Ouyang Hong Wei HW Crane Janet J Zhou Feng-Quan FQ Guan Yun Y Dong Xinzhong X Cao Xu X
The Journal of clinical investigation 20190204 3
Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated subchondral bone remodeling in sensory innervation for OA pain. We show that osteoclasts secrete netrin-1 to induce sensory nerve axonal growth in subchondral bone. Reduction of osteoclast formation by knockout of receptor activator of nuclear factor kappa-B ligand (Rankl) in osteocytes inhibited the growth of sensory nerves i ...[more]