Ontology highlight
ABSTRACT:
SUBMITTER: Karsai G
PROVIDER: S-EPMC6391115 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Karsai Gergely G Kraft Florian F Haag Natja N Korenke G Christoph GC Hänisch Benjamin B Othman Alaa A Suriyanarayanan Saranya S Steiner Regula R Knopp Cordula C Mull Michael M Bergmann Markus M Schröder J Michael JM Weis Joachim J Elbracht Miriam M Begemann Matthias M Hornemann Thorsten T Kurth Ingo I
The Journal of clinical investigation 20190211 3
<h4>Background</h4>Sphingolipids are important components of cellular membranes and functionally associated with fundamental processes such as cell differentiation, neuronal signaling, and myelin sheath formation. Defects in the synthesis or degradation of sphingolipids leads to various neurological pathologies; however, the entire spectrum of sphingolipid metabolism disorders remains elusive.<h4>Methods</h4>A combined approach of genomics and lipidomics was applied to identify and characterize ...[more]