Spike-timing-dependent ensemble encoding by non-classically responsive cortical neurons.

ABSTRACT: Neurons recorded in behaving animals often do not discernibly respond to sensory input and are not overtly task-modulated. These non-classically responsive neurons are difficult to interpret and are typically neglected from analysis, confounding attempts to connect neural activity to perception and behavior. Here, we describe a trial-by-trial, spike-timing-based algorithm to reveal the coding capacities of these neurons in auditory and frontal cortex of behaving rats. Classically responsive and non-classically responsive cells contained significant information about sensory stimuli and behavioral decisions. Stimulus category was more accurately represented in frontal cortex than auditory cortex, via ensembles of non-classically responsive cells coordinating the behavioral meaning of spike

SUBMITTER: Insanally MN 

PROVIDER: S-EPMC6391134 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature