MicroRNAs, Hypoxia and the Stem-Like State as Contributors to Cancer Aggressiveness.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNA molecules that play key regulatory roles in cancer acting as both oncogenes and tumor suppressors. Due to their potential roles in improving cancer prognostic, predictive, diagnostic and therapeutic approaches, they have become an area of intense research focus in recent years. Several studies have demonstrated an altered expression of several miRNAs under hypoxic condition and even shown that the hypoxic microenvironment drives the selection of a more aggressive cancer cell population through cellular adaptations referred as the cancer stem-like cell. These minor fractions of cells are characterized by their self-renewal abilities and their ability to maintain the tumor mass, suggesting their crucial roles in cancer development. This review aims

SUBMITTER: Macharia LW 

PROVIDER: S-EPMC6391339 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature