Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez R
PROVIDER: S-EPMC6391402 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Hernandez Reinier R Walker Kirsti L KL Grudzinski Joseph J JJ Aluicio-Sarduy Eduardo E Patel Ravi R Zahm Christopher D CD Pinchuk Anatoly N AN Massey Christopher F CF Bitton Ariana N AN Brown Ryan J RJ Sondel Paul M PM Morris Zachary S ZS Engle Jonathan W JW Capitini Christian M CM Weichert Jamey P JP
Communications biology 20190226
Finding improved therapeutic strategies against T-cell Non-Hodgkin's Lymphoma (NHL) remains an unmet clinical need. We implemented a theranostic approach employing a tumor-targeting alkylphosphocholine (NM600) radiolabeled with <sup>86</sup>Y for positron emission tomography (PET) imaging and <sup>90</sup>Y for targeted radionuclide therapy (TRT) of T-cell NHL. PET imaging and biodistribution performed in mouse models of T-cell NHL showed in vivo selective tumor uptake and retention of <sup>86</ ...[more]