Tumor-Targeted and Biocompatible MoSe₂ Nanodots@Albumin Nanospheres as a Dual-Modality Therapy Agent for Synergistic Photothermal Radiotherapy.

ABSTRACT: Integrating multiple tumor therapy functions into one nanoplatform has been a new tumor therapy strategy in recent years. Herein, a dual-modality therapy agent consisting of molybdenum selenide nanodots (MoSe₂ NDs) and bovine serum albumin (BSA) assembled nanospheres (MoSe₂@BSA NSs) was successfully synthesized. After conjugation of folic acid (FA) molecules via polyethylene glycol (PEG) "bridges," the FA-MoSe₂@BSA NSs were equipped with tumor-targeting function. The BSA and PEG modifications provided the unstable MoSe₂ NDs with excellent physiological stability. Since the end-product FA-MoSe₂@BSA NSs had strong near-infrared (NIR) and X-ray absorbance properties, they exhibited good photothermal properties with excellent photothermal

SUBMITTER: Qi F 

PROVIDER: S-EPMC6391510 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature