Ontology highlight
ABSTRACT:
SUBMITTER: Figueira-Mansur J
PROVIDER: S-EPMC6391532 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Figueira-Mansur Janaina J Aguilera Estefania A EA Stoque Rafael M RM Ventura Gustavo T GT Mohana-Borges Ronaldo R
Scientific reports 20190226 1
The dengue virus 2 capsid protein (DENV2C) plays a primary structural role in the protection of the viral genome and is crucial for nucleocapsid assembly. In this study, we generated single mutants of DENV2C at L50 and L54 residues of the α2 helix, which was shown to interfere with the integration of the capsid into lipid droplets, and at residues L81 and I88 located in the α4 helix, which was shown to affect viral assembly. We demonstrated that the oligomeric states of DENV2C and its mutants ex ...[more]