Use of amantadine as substrate for SSAT-1 activity as a reliable clinical diagnostic assay for breast and lung cancer.
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ABSTRACT:
SUBMITTER: Maksymiuk AW
PROVIDER: S-EPMC6391627 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Use of amantadine as substrate for SSAT-1 activity as a reliable clinical diagnostic assay for breast and lung cancer.
Maksymiuk Andrew W AW Tappia Paramjit S PS Sitar Daniel S DS Akhtar Parveen S PS Khatun Nazrina N Parveen Rahnuma R Ahmed Rashiduzzaman R Ahmed Rashid Bux RB Cheng Brian B Huang Gina G Bach Horacio H Hiebert Brett B Ramjiawan Bram B
Future science OA 20181211 2
<h4>Aim</h4>Spermidine/spermine N<sup>1</sup>-acetyltransferase (SSAT-1) plays a critical role in cell growth, proliferation and death, and is known to be activated in human cancer cells. Amantadine, a US FDA-approved antiviral drug, is a substrate for SSAT-1 and can be used to indirectly measure SSAT-1 activity because of its conversion to acetylamantadine (AA). This study was undertaken to further validate SSAT-1 activity in breast and lung cancer patients.<h4>Results</h4>An increase in the ur ...[more]
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