Translation regulation in skin cancer from a tRNA point of view.
Ontology highlight
ABSTRACT:
SUBMITTER: Grafanaki K
PROVIDER: S-EPMC6391632 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Translation regulation in skin cancer from a tRNA point of view.
Grafanaki Katerina K Anastasakis Dimitrios D Kyriakopoulos George G Skeparnias Ilias I Georgiou Sophia S Stathopoulos Constantinos C
Epigenomics 20181219 2
Protein synthesis is a central and dynamic process, frequently deregulated in cancer through aberrant activation or expression of translation initiation factors and tRNAs. The discovery of tRNA-derived fragments, a new class of abundant and, in some cases stress-induced, small Noncoding RNAs has perplexed the epigenomics landscape and highlights the emerging regulatory role of tRNAs in translation and beyond. Skin is the biggest organ in human body, which maintains homeostasis of its multilayers ...[more]
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