Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Manero G
PROVIDER: S-EPMC6391673 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Garcia-Manero Guillermo G Abaza Yasmin Y Takahashi Koichi K Medeiros Bruno C BC Arellano Martha M Khaled Samer K SK Patnaik Mrinal M Odenike Olatoyosi O Sayar Hamid H Tummala Mohan M Patel Prapti P Maness-Harris Lori L Stuart Robert R Traer Elie E Karamlou Kasra K Yacoub Abdulraheem A Ghalie Richard R Giorgino Ruben R Atallah Ehab E
Blood advances 20190201 4
Pracinostat, a potent oral pan-histone deacetylase inhibitor with modest single-agent activity in acute myeloid leukemia (AML), has shown synergistic antitumor activity when combined with azacitidine. This single-group, multicenter phase 2 study assessed the safety and efficacy of pracinostat combined with azacitidine in patients who were at least 65 years old with newly diagnosed AML and who were ineligible for standard induction chemotherapy. Patients received pracinostat 60 mg/d, 3 d/wk, for ...[more]