Effect of Hypoglycemia on Inflammatory Responses and the Response to Low-Dose Endotoxemia in Humans.

ABSTRACT:

Context

Hypoglycemia is emerging as a risk for cardiovascular events in diabetes. We hypothesized that hypoglycemia activates the innate immune system, which is known to increase cardiovascular risk.

Objective

To determine whether hypoglycemia modifies subsequent innate immune system responses.

Design and setting

Single-blinded, prospective study of three independent parallel groups.

Participants and interventions

Twenty-four healthy participants underwent either a hyperinsulinemic-hypoglycemic (2.5 mmol/L), euglycemic (6.0 mmol/L), or sham-saline clamp (n = 8 for each group). After 48 hours, all participants received low-dose (0.3 ng/kg) intravenous endotoxin.

Main outcome measures

We studied in-vivo monocyte mobilization and monocyte-platelet interacti

SUBMITTER: Iqbal A 

PROVIDER: S-EPMC6391720 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature