Practice variation in anti-epileptic drug use for neonatal hypoxic-ischemic encephalopathy among regional NICUs.

ABSTRACT: BACKGROUND:While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systematically evaluated. This is important as these centers typically have multidisciplinary neonatal neurocritical care teams and protocolized approaches to treating conditions such as hypoxic ischemic encephalopathy (HIE), a population at high risk for neonatal seizures. To identify opportunities for quality improvement (QI), we evaluated ICV in AED utilization for neonates with HIE treated with therapeutic hypothermia (TH) across regional NICUs in the US. METHODS:Children's Hospital Neonatal Database and Pediatric Health Information Systems data were linked for 1658 neonates ≥

SUBMITTER: Dizon MLV 

PROVIDER: S-EPMC6391819 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature