Ontology highlight
ABSTRACT:
SUBMITTER: Tan Y
PROVIDER: S-EPMC6391854 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Tan Yiao Y Zhang Tengyue T Zhou Linyu L Liu Shuhan S Liang Chaozhao C
Medical science monitor : international medical journal of experimental and clinical research 20190219
BACKGROUND Chemoresistance is a main limitation in chemotherapy for therapeutic cancer. MicroRNA (miRNA) has been indicated in the progression and tumorigenesis of many types of cancer, but the effect of miR-34b-3p in bladder cancer (BCa) cells is still unknown. MATERIAL AND METHODS This research compared the multidrug-sensitive (5637) BCa cell line and the multidrug-resistant (EJ) BCa cell line. We found that CCND2 (G1/S-specific cyclin-D2) and P2RY1 (purinergic receptor P2Y1) were the targets ...[more]