Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC6391939 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Xu Jin J Green Anthony P AP Turner Nicholas J NJ
Angewandte Chemie (International ed. in English) 20181121 51
Herein we report the biocatalytic synthesis of substituted pyrazines and pyrroles using a transaminase (ATA) to mediate the key amination step of the ketone precursors. Treatment of α-diketones with ATA-113 in the presence of a suitable amine donor yielded the corresponding α-amino ketones which underwent oxidative dimerization to the pyrazines. Selective amination of α-diketones in the presence of β-keto esters afforded substituted pyrroles in a biocatalytic equivalent of the classical Knorr py ...[more]