Polyoxometalates as Potential Next-Generation Metallodrugs in the Combat Against Cancer.

ABSTRACT: Polyoxometalates (POMs) are an emerging class of inorganic metal oxides, which over the last decades demonstrated promising biological activities by the virtue of their great diversity in structures and properties. They possess high potential for the inhibition of various tumor types; however, their unspecific interactions with biomolecules and toxicity impede their clinical usage. The current focus of the field of biologically active POMs lies on organically functionalized and POM-based nanocomposite structures as these hybrids show enhanced anticancer activity and significantly reduced toxicity towards normal cells in comparison to unmodified POMs. Although the antitumor activity of POMs is well documented, their mechanisms of action are still not well understood. In this Review, an over

SUBMITTER: Bijelic A 

PROVIDER: S-EPMC6391951 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature