Plasticity at Thalamo-amygdala Synapses Regulates Cocaine-Cue Memory Formation and Extinction.
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ABSTRACT:
SUBMITTER: Rich MT
PROVIDER: S-EPMC6392072 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
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Plasticity at Thalamo-amygdala Synapses Regulates Cocaine-Cue Memory Formation and Extinction.
Rich Matthew T MT Huang Yanhua H YH Torregrossa Mary M MM
Cell reports 20190101 4
Repeated drug use has long-lasting effects on plasticity throughout the brain's reward and memory systems. Environmental cues that are associated with drugs of abuse can elicit craving and relapse, but the neural circuits responsible for driving drug-cue-related behaviors have not been well delineated, creating a hurdle for the development of effective relapse prevention therapies. In this study, we used a cocaine+cue self-administration paradigm followed by cue re-exposure to establish that the ...[more]
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