Dataset Information

Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers.

ABSTRACT:

Objective

The objective of this study was to compare physical activity energy expenditure (PAEE) and total daily energy expenditure (TDEE) in successful weight loss maintainers (WLM) with normal weight controls (NC) and controls with overweight/obesity (OC).

Methods

Participants were recruited in three groups: WLM (n?=?25, BMI 24.1?±?2.3 kg/m² ; maintaining ??13.6-kg weight loss for ??1 year), NC (n?=?27, BMI 23.0?±?2.0 kg/m² ; similar to current BMI of WLM), and OC (n?=?28, BMI 34.3?±?4.8 kg/m² ; similar to pre-weight loss BMI of WLM). TDEE was measured using the doubly labeled water method. Resting energy expenditure (REE) was measured using indirect calorimetry. PAEE was calculated as (TDEE?-?[0.1?×?TDEE]?-?REE).

Results

PAEE in WLM (812?±?268 kcal/d, mean?±?SD) was significantly higher compared with that in both NC (621?±?285 kcal/d, P?ConclusionsThe high levels of PAEE and TDEE observed in individuals maintaining a substantial weight loss (-26.2?±?9.8 kg maintained for 9.0?±?10.2 years) suggest that this group relies on high levels of energy expended in physical activity to remain in energy balance (and avoid weight regain) at a reduced body weight.

SUBMITTER: Ostendorf DM

PROVIDER: S-EPMC6392078 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers.

Ostendorf Danielle M DM Caldwell Ann E AE Creasy Seth A SA Pan Zhaoxing Z Lyden Kate K Bergouignan Audrey A MacLean Paul S PS Wyatt Holly R HR Hill James O JO Melanson Edward L EL Catenacci Victoria A VA

Obesity (Silver Spring, Md.) 20190301 3

<h4>Objective</h4>The objective of this study was to compare physical activity energy expenditure (PAEE) and total daily energy expenditure (TDEE) in successful weight loss maintainers (WLM) with normal weight controls (NC) and controls with overweight/obesity (OC).<h4>Methods</h4>Participants were recruited in three groups: WLM (n = 25, BMI 24.1 ± 2.3 kg/m<sup>2</sup> ; maintaining ≥ 13.6-kg weight loss for ≥ 1 year), NC (n = 27, BMI 23.0 ± 2.0 kg/m<sup>2</sup> ; similar to current BMI of WLM), ...[more]

PMID: 30801984

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Project description:BackgroundWeight gain is associated with deterioration in metabolic health, whereas weight loss improves insulin sensitivity. This study assesses the impact of long-term, successfully maintained weight loss and weight-loss relapse on measures of insulin sensitivity and identifies factors that explain variability in insulin sensitivity.MethodsWomen (20-45 years) were recruited into four groups: reduced-overweight/obese (RED, n=15); body mass index (BMI)-matched controls (stable low-weight, n=19), BMI?27?kg?m-2; relapsed-overweight/obese subjects (REL, n=11); and BMI-matched controls (obese stable weight, n=11), BMI?27?kg?m-2. A 75?g oral glucose tolerance test determined fasting and 2?h plasma glucose and insulin. Homeostatic Model Assessment (HOMA-IR) and insulin sensitivity index (ISI(0,120)) assessed insulin sensitivity. Anthropometric measurements, fasting resting metabolic rate (RMR) and respiratory quotient (RQ) were measured. Questionnaires and dietary intake were recorded, and physical activity was measured using accelerometers.ResultsRED were more insulin sensitive, characterised by lower fasting (P=0.001) and 2?h insulin (P=0.003) levels compared with all other groups. There were no significant differences in dietary intake, sedentary, light and moderate activity, RMR or RQ in the RED compared with the other three groups. % Body weight (BW) lost (P<0.001), % BW regained (P<0.05), body fat %, light activity (P<0.05, only log HOMA), vigorous activity (P<0.05) and RQ (P<0.01) predicted 61.4% and 59.7% of variability in log HOMA and log ISI(0,120), respectively, in multiple linear regression models.ConclusionThis study showed sustained enhanced insulin sensitivity in successful weight loss maintainers compared with BMI-matched controls with no weight loss history. Weight-loss-relapsed individuals were indistinguishable from controls. Weight loss itself was the strongest predictor of improved insulin sensitivity, whereas weight regain significantly predicted reduced insulin sensitivity. Weight-loss maintenance programs are essential to retaining metabolic benefits acquired through weight loss. Being physically active, reducing sedentary behaviour and, in particular, including small amounts of vigorous physical activity significantly predicted improved insulin sensitivity.

Dataset Information

Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers.

Objective

Methods

Results

Publications

Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers.

Similar Datasets

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