Ontology highlight
ABSTRACT:
SUBMITTER: Ohradanova-Repic A
PROVIDER: S-EPMC6392118 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Journal of leukocyte biology 20190118 3
The plasminogen system is harnessed in a wide variety of physiological processes, such as fibrinolysis, cell migration, or efferocytosis; and accordingly, it is essential upon inflammation, tissue remodeling, wound healing, and for homeostatic maintenance in general. Previously, we identified a plasminogen receptor in the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R, CD222). Here, we demonstrate by means of genetic knockdown, knockout, and rescue approaches combined with ...[more]