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Auto-Crosslinked Rigid Foams Derived from Biorefinery Byproducts.

ABSTRACT: A new macroporous foam-like material is presented based on autocross-linking humins, an industrial biorefinery byproduct. Humins foams are obtained by a simple heating process, without any pretreatment and with high control of morphology, porosity, and carbon content. Untreated humins have been characterized by GC, ultra-performance liquid chromatography (UPLC), elemental analysis, and FTIR, whereas the mechanism of foaming was elucidated by a combination of thermal and rheological analyses. A preliminary screening of conditions was conducted to identify the parameters controlling this foaming process. A foam was produced in a controlled way with open and/or closed cells with cell diameters between 0.2 and 3.5?mm. Humins foams were characterized by Raman spectroscopy, FTIR, SEM, nitrogen adsorption, pycnometry, and mechanical tests. The results show that, based on humins, it is possible to obtain porous materials with controlled architectures and a range of parameters that can be tailored, depending on the foreseen applications.

SUBMITTER: Tosi P

PROVIDER: S-EPMC6392144 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Auto-Crosslinked Rigid Foams Derived from Biorefinery Byproducts.

Tosi Pierluigi P van Klink Gerard P M GPM Celzard Alain A Fierro Vanessa V Vincent Luc L de Jong Ed E Mija Alice A

ChemSusChem 20180725 16

A new macroporous foam-like material is presented based on autocross-linking humins, an industrial biorefinery byproduct. Humins foams are obtained by a simple heating process, without any pretreatment and with high control of morphology, porosity, and carbon content. Untreated humins have been characterized by GC, ultra-performance liquid chromatography (UPLC), elemental analysis, and FTIR, whereas the mechanism of foaming was elucidated by a combination of thermal and rheological analyses. A p ...[more]

PMID: 29956889

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Project description:Platelet-rich plasma (PRP) associated with high molecular weight hyaluronic acid (HA) has been clinically used for tissue regeneration in orthopedics. Despite the recognized beneficial clinical outcomes (e.g., early pain control, improvement of patients' functional limitation and longer-term effectiveness compared to PRP and HA alone in mild and moderate osteoarthritis treatments), its use is still challenging and controversial due to lack of standardization of association practical protocols. Moreover, most studies neglect the matrix structure, that generates the ultimate properties of the association among platelets, fibrin network and the microparticles. In the present work, we aimed to analyze the influence of the PRP/HA association with a controlled matrix structure on the stability, rheological behavior, release of growth factors and in vitro proliferation of human adipose-derived mesenchymal cells (h-AdMSCs). The attenuation of the negative charge of HA was also evaluated. Pure PRP (P-PRP) (i.e., plasma enriched with platelets and poor in leukocytes) was prepared by centrifugation and activated with serum and calcium chloride (AP-PRP). Autocrosslinked hyaluronic acid (AHA) was prepared by organocatalyzed auto-esterification and structured in microparticles (MPAHA) by shearing. The attenuation of the negative charge of MPAHA was performed with chitosan (CHT) by polyelectrolyte complexation yielding MPAHA-CHT. The results showed that microparticles (MPs) have viscoelastic properties, extrusion force and swelling ratio appropriate for injectable applications. The association of AP-PRP with the controlled structure of MPAHA and MPAHA-CHT formed a matrix composed of platelets and of a fibrin network with fibers around 160 nm located preferably on the surface of the MPs with an average diameter of 250 ?m. Moreover, AP-PRP/MPAHA and AP-PRP/MPAHA-CHT associations were non-toxic and supported controlled growth factor (PDGF-AB and TGF-?1) release and in vitro proliferation of h-AdMSC with a similar pattern to that of AP-PRP alone. The best h-AdMSC proliferation was obtained with the AP-PRP/MPAHA-CHT75:25 indicating that the charge attenuation improved the cell proliferation. Thus, the association of AP-PRP with the controlled structure of HA can be a valuable approach for orthopedic applications.

Dataset Information

Auto-Crosslinked Rigid Foams Derived from Biorefinery Byproducts.

Publications

Auto-Crosslinked Rigid Foams Derived from Biorefinery Byproducts.

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