Ontology highlight
ABSTRACT:
SUBMITTER: Chwalenia K
PROVIDER: S-EPMC6393300 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Chwalenia Katarzyna K Qin Fujun F Singh Sandeep S Li Hui H
Nucleic acids research 20190201 4
Chimeric RNAs generated by cis-splicing between adjacent genes (cis-SAGe) are increasingly recognized as a widespread phenomenon. These chimeric messenger RNAs are present in normal human cells, and are also detected in various cancers. The mechanisms for how this group of chimeras is formed are not yet clear, in part due to the lack of a tractable system for their experimental investigation. Here we developed a fast, easy and versatile cell-based reporter system to identify regulators of cis-SA ...[more]