Ontology highlight
ABSTRACT:
SUBMITTER: Pradhan MR
PROVIDER: S-EPMC6393305 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Pradhan Mohan R MR Siau Jia Wei JW Kannan Srinivasaraghavan S Nguyen Minh N MN Ouaray Zohra Z Kwoh Chee Keong CK Lane David P DP Ghadessy Farid F Verma Chandra S CS
Nucleic acids research 20190201 4
The DNA binding domain (DBD) of the tumor suppressor p53 is the site of several oncogenic mutations. A subset of these mutations lowers the unfolding temperature of the DBD. Unfolding leads to the exposure of a hydrophobic β-strand and nucleates aggregation which results in pathologies through loss of function and dominant negative/gain of function effects. Inspired by the hypothesis that structural changes that are associated with events initiating unfolding in DBD are likely to present opportu ...[more]