Five-year prognostic significance of global longitudinal strain in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes.
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ABSTRACT:
SUBMITTER: van Velzen HG
PROVIDER: S-EPMC6393574 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Five-year prognostic significance of global longitudinal strain in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes.
van Velzen H G HG Schinkel A F L AFL van Grootel R W J RWJ van Slegtenhorst M A MA van der Velden J J Strachinaru M M Michels M M
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20190301 3
<h4>Background</h4>Previous studies have reported that global longitudinal strain (GLS) is reduced in patients with hypertrophic cardiomyopathy (HCM) while left ventricular ejection fraction (LVEF) is normal. Our aim was to assess GLS in individuals with HCM mutations without hypertrophic changes and to determine its prognostic value for the development of HCM.<h4>Methods and results</h4>This retrospective case-control and cohort study included 120 HCM mutation carriers and 110 controls. GLS and ...[more]
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