Ontology highlight
ABSTRACT:
SUBMITTER: Lundberg A
PROVIDER: S-EPMC6394106 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Lundberg Arian A Lindström Linda S LS Li Jingmei J Harrell J Chuck JC Darai-Ramqvist Eva E Sifakis Emmanouil G EG Foukakis Theodoros T Perou Charles M CM Czene Kamila K Bergh Jonas J Tobin Nicholas P NP
Breast cancer research : BCR 20190228 1
<h4>Background</h4>Use of cyclin D1 (CCND1) gene amplification as a breast cancer biomarker has been hampered by conflicting assessments of the relationship between cyclin D1 protein levels and patient survival. Here, we aimed to clarify its prognostic and treatment predictive potential through comprehensive long-term survival analyses.<h4>Methods</h4>CCND1 amplification was assessed using SNP arrays from two cohorts of 1965 and 340 patients with matching gene expression array and clinical follo ...[more]