A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella.
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ABSTRACT:
SUBMITTER: Ledvina HE
PROVIDER: S-EPMC6394229 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella.
Ledvina Hannah E HE Kelly Katherine A KA Eshraghi Aria A Plemel Rachael L RL Peterson S Brook SB Lee Brian B Steele Shaun S Adler Marlen M Kawula Thomas H TH Merz Alexey J AJ Skerrett Shawn J SJ Celli Jean J Mougous Joseph D JD
Cell host & microbe 20180726 2
Many pathogenic intracellular bacteria manipulate the host phago-endosomal system to establish and maintain a permissive niche. The fate and identity of these intracellular compartments is controlled by phosphoinositide lipids. By mechanisms that have remained undefined, a Francisella pathogenicity island-encoded secretion system allows phagosomal escape and replication of bacteria within host cell cytoplasm. Here we report the discovery that a substrate of this system, outside pathogenicity isl ...[more]
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