Ontology highlight
ABSTRACT:
SUBMITTER: Zong Z
PROVIDER: S-EPMC6394306 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Zong Zhenkun Z Hua Lei L Wang Zhen Z Xu Haoyue H Ye Chengkun C Pan Bomin B Zhao Zongren Z Zhang Longzhen L Lu Jun J Mei Liu Hong LH Rutong Yu Y
Drug delivery 20191201 1
The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in patients. In this study, we prepared angiopep-2 (A2) modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles for TMZ delivery (A2-P(MIs)25/TMZ) to achieve synergistic effects against glioma. This A2-P(MIs)25/TMZ display highly promising advantages: (1) a hydrophobic P-(MIs)25 core where poorly water-soluble TMZ can be encapsula ...[more]