Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism.

ABSTRACT:

Background and objective

The possible adverse or positive effects of levothyroxine treatment among patients with atrial fibrillation have been debated. Atrial fibrillation, levothyroxine treatment, and dementia are common among older adults, yet little is known about the effects of levothyroxine on the development of dementia.

Methods

The study population included all adults (n = 12,057) aged ≥ 45 years with a diagnosis of atrial fibrillation at 75 primary care centers in Sweden during 2001-2007 without an earlier recorded dementia diagnosis. Patients with a diagnosis of hypothyroidism and levothyroxine prescription (n = 756; 180 men and 576 women), or with a prescription without this diagnosis (n = 415, 100 men and 315 women), were compared to patients without a diagnosis a

SUBMITTER: Wandell P 

PROVIDER: S-EPMC6394624 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature