Ontology highlight
ABSTRACT:
SUBMITTER: Oukoloff K
PROVIDER: S-EPMC6394845 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20190114
The 1,2,4-triazolo[1,5-a]pyrimidine (TP) heterocycle, in spite of its relatively simple structure, has proved to be remarkably versatile as evidenced by its use in many different applications reported over the years in different areas of drug design. For example, as the ring system of TPs is isoelectronic with that of purines, this heterocycle has been proposed as a possible surrogate of the purine ring. However, depending on the choice of substituents, the TP ring has also been described as a p ...[more]