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1,2,4-Triazolo[1,5-a]pyrimidines in drug design.

ABSTRACT: The 1,2,4-triazolo[1,5-a]pyrimidine (TP) heterocycle, in spite of its relatively simple structure, has proved to be remarkably versatile as evidenced by its use in many different applications reported over the years in different areas of drug design. For example, as the ring system of TPs is isoelectronic with that of purines, this heterocycle has been proposed as a possible surrogate of the purine ring. However, depending on the choice of substituents, the TP ring has also been described as a potentially viable bio-isostere of the carboxylic acid functional group and of the N-acetyl fragment of ?-N-acetylated lysine. In addition, the metal-chelating properties of the TP ring have also been exploited to generate candidate treatments for cancer and parasitic diseases. In the present review article, we discuss recent applications of the TP scaffold in medicinal chemistry, and provide an overview of its properties and methods of synthesis.

SUBMITTER: Oukoloff K

PROVIDER: S-EPMC6394845 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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1,2,4-Triazolo[1,5-a]pyrimidines in drug design.

Oukoloff Killian K Lucero Bobby B Francisco Karol R KR Brunden Kurt R KR Ballatore Carlo C

European journal of medicinal chemistry 20190114

The 1,2,4-triazolo[1,5-a]pyrimidine (TP) heterocycle, in spite of its relatively simple structure, has proved to be remarkably versatile as evidenced by its use in many different applications reported over the years in different areas of drug design. For example, as the ring system of TPs is isoelectronic with that of purines, this heterocycle has been proposed as a possible surrogate of the purine ring. However, depending on the choice of substituents, the TP ring has also been described as a p ...[more]

PMID: 30703745

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