Dataset Information

The use of a functional test battery as a non-invasive method of fatigue assessment.

ABSTRACT: To assess whether a battery of performance markers, both individually and as group, would be sensitive to fatigue, a within group random cross-over design compared multiple variables during seated control and fatigue (repeated sprint cycling) conditions. Thirty-two physically active participants completed a neuromuscular fatigue questionnaire, Stroop task, postural sway, squat jump, countermovement jump, isometric mid-thigh pull and 10 s maximal sprint cycle (Sprintmax) before and after each condition (15 min, 1 h, 24 h and 48 h). In comparison to control, larger neuromuscular fatigue questionnaire total score decrements were observed 15 min (5.20 ± 4.6), 1 h (3.33 ± 3.9) and 24 h (1.83 ± 4.8) after cycling. Similarly, the fatigue condition elicited greater declines than control at 15 min and 1 h post in countermovement jump height (1.67 ± 1.90 cm and 1.04 ± 2.10 cm), flight time-contraction time ratio (0.03 ± 0.06 and 0.05 ± 0.11), and velocity (0.06 ± 0.07 m?s-1 and 0.04 ± 0.08 m?s-1). After fatigue, decrements were observed up to 48 h for average Sprintmax cadence (4-6 RPM), up to 24 h in peak Sprintmax cadence (2-5 RPM) and up to 1 h in average and peak Sprintmax power (45 ± 60 W and 58 ± 71 W). Modelling variables in a stepwise regression demonstrated that CMJ height explained 53.2% and 51.7% of 24 h and 48 h Sprintmax average power output. Based upon these data, the fatigue induced by repeated sprint cycling coincided with changes in the perception of fatigue and markers of performance during countermovement and squat jumps. Furthermore, multiple regression modelling revealed that a single variable (countermovement jump height) explained average power output.

SUBMITTER: Hughes S

PROVIDER: S-EPMC6394954 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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The use of a functional test battery as a non-invasive method of fatigue assessment.

Hughes Steven S Chapman Dale W DW Haff G Gregory GG Nimphius Sophia S

PloS one 20190228 2

To assess whether a battery of performance markers, both individually and as group, would be sensitive to fatigue, a within group random cross-over design compared multiple variables during seated control and fatigue (repeated sprint cycling) conditions. Thirty-two physically active participants completed a neuromuscular fatigue questionnaire, Stroop task, postural sway, squat jump, countermovement jump, isometric mid-thigh pull and 10 s maximal sprint cycle (Sprintmax) before and after each con ...[more]

PMID: 30817785

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Project description:BackgroundEstablishing a high-accuracy and non-invasive method is essential for evaluating cardiovascular disease. Skin cholesterol is a novel marker for assessing the risk of atherosclerosis and can be used as an independent risk factor of early assessment of atherosclerotic risk.MethodsWe propose a non-invasive skin cholesterol detection method based on absorption spectroscopy. Detection reagents specifically bind to skin cholesterol and react with indicator to produce colored products, the skin cholesterol content can be obtained through absorption spectrum information on colored products detected by non-invasive technology. Gas chromatography is used to measure cholesterol extracted from the skin to verify the accuracy and reliability of the non-invasive test method. A total of 342 subjects were divided into normal group (n = 115), disease group (n = 110) and risk group (n = 117). All subjects underwent non-invasive skin cholesterol test. The diagnostic accuracy of the measured value was analyzed by receiver-operating characteristic (ROC) curve.ResultsThe proposed method is able to identify porcine skin containing gradient concentration of cholesterol. The values measured by non-invasive detection method were significantly correlated with gas chromatography measured results (r = 0.9074, n = 73, p < 0.001). Bland-Altman bias was - 72.78 ± 20.03 with 95% limits of agreement - 112.05 to - 33.51, falling within the prespecified clinically non-significant range. We further evaluated the method of patients with atherosclerosis and risk population as well as normal group, patients and risk atherosclerosis group exhibited higher skin cholesterol content than normal group (all P < 0.001). The area under the ROC curve for distinguishing Normal/Disease group was 0.8642 (95% confidence interval, 0.8138 to 0.9146), meanwhile, the area under the ROC curve for distinguishing Normal/Risk group was 0.8534 (95% confidence interval, 0.8034 to 0.9034).ConclusionsThe method demonstrated its capability of detecting different concentration of skin cholesterol. This non-invasive skin cholesterol detection system may potentially be used as a risk assessment tool for atherosclerosis screening, especially for a large population.

Project description:Helicobacter pylori (H. pylori) can cause gastritis, peptic ulcer diseases and gastric carcinoma. Endoscopy as the gold standard method of diagnosis is an invasive procedure that might not be suitable in all scenarios. Therefore, this first study in Jordan aimed to assess the non-invasive 13C urea breath test (UBT) and stool antigen test for diagnosis of H. pylori infection and the successfulness of eradication therapy as alternatives for endoscopy. Hence, a total of 30 patients attending the endoscopy units at Alkarak teaching hospital were asked to complete a questionnaire with demographic and clinical data. They were then tested for H. pylori using 13C UBT and H. pylori stool antigen before having endoscopy. Another 30 patients who were positive for H. pylori by endoscopy were tested using both tests 6 weeks post eradication therapy. Results showed that the rate of H. pylori detection using endoscopy was 56.7% (17/30). Heartburns (82.3%, p value = 0.019), epigastric pain (88.2%, p value = 0.007) and vomiting (70.5%, p value = 0.02) were the most significant symptoms. Family history of peptic ulcer diseases was significantly associated with an increased risk for having a H. pylori positive result (p value = 0.02). Compared to endoscopy, the sensitivity of 13C UBT for the diagnosis of H. pylori was 94.1% (16/17), while it was 76.5% (13/17) for the stool antigen test. The specificity of both tests was equal (76.9%). However, the positive predictive and negative predictive values (84.2% and 90.9%) for 13C UBT were higher than those (81.3% and 71.4%) for the stool antigen test. The accuracy of 13C UBT was 86.7% compared to 76.7% for the stool antigen test. There was an 87% agreement (20 patients out of 23) between both tests when used to assess success of the eradication therapy. In conclusion, the 13C UBT was found to be more sensitive and accurate than the stool antigen test when used for diagnosis; furthermore, it has a comparable outcome to the stool antigen test in assessing the successfulness of the eradication treatment.

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The use of a functional test battery as a non-invasive method of fatigue assessment.

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The use of a functional test battery as a non-invasive method of fatigue assessment.

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