Clinical, Diagnostic, and Treatment Characteristics of <i>SDHA</i>-Related Metastatic Pheochromocytoma and Paraganglioma.

ABSTRACT: Background: Pheochromocytoma and paraganglioma (PHEO/PGL) are rare neuroendocrine tumors which may cause potentially life-threatening complications, with about a third of cases found to harbor specific gene mutations. Thus, early diagnosis, treatment, and meticulous monitoring are of utmost importance. Because of low incidence of succinate dehydrogenase complex subunit A (SDHA)-related metastatic PHEO/PGL, currently there exists insufficient clinical information, especially with regards to its diagnostic and treatment characteristics. Methods: Ten patients with SDHA-related metastatic PHEO/PGL were followed-up prospectively and/or retrospectively between January 2010-July 2018. They underwent biochemical tests (n = 10), ¹²³I-MIBG (n = 9)

SUBMITTER: Jha A 

PROVIDER: S-EPMC6395427 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature