Ontology highlight
ABSTRACT:
SUBMITTER: Lopez J
PROVIDER: S-EPMC6395714 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Lopez Joseph J Quan Amy A Budihardjo Joshua J Xiang Sinan S Wang Howard H Kiron Koshy Cashman Christopher C Lee W P Andrew WPA Hoke Ahmet A Tuffaha Sami S Brandacher Gerald G
Scientific reports 20190228 1
This study investigates the efficacy of systemic growth hormone (GH) therapy in ameliorating the deleterious effects of chronic denervation (CD) injury on nerve regeneration and resulting motor function. Using a forelimb CD model, 4 groups of Lewis rats were examined (n = 8 per group): Group-1 (negative control) 8 weeks of median nerve CD followed by ulnar-to-median nerve transfer; Group-2 (experimental) 8 weeks of median nerve CD followed by ulnar-to-median nerve transfer and highly purified ly ...[more]