Ontology highlight
ABSTRACT:
SUBMITTER: Duciel L
PROVIDER: S-EPMC6395723 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20190228 1
Uveal melanoma (UM) is an aggressive tumor in which approximately 50% of patients develop metastasis. Expression of the PTP4A3 gene, encoding a phosphatase, is predictive of poor patient survival. PTP4A3 expression in UM cells increases their migration in vitro and invasiveness in vivo. Here, we show that CRMP2 is mostly dephosphorylated on T514 in PTP4A3 expressing cells. We also demonstrate that inhibition of CRMP2 expression in UM cells expressing PTP4A3 increases their migration in vitro and ...[more]