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Emergence of a Multidrug-Resistant Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strain with a Rare bla CTX-M-24-Harboring Virulence Plasmid.

ABSTRACT: Here, we report a multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-HvKP) strain of sequence type 23 (ST23) with a rare hybrid plasmid harboring virulence genes and bla CTX-M-24, and we analyze the genetic basis for relationship between genotypes and MDR-hypervirulence phenotypes. Further analysis indicates that the hybrid plasmid is formed by IS903D-mediated intermolecular transposition of the bla CTX-M-24 gene into the virulence plasmid. The emergence of MDR-HvKP strains, especially those carrying drug-resistant virulent plasmids, poses unprecedented threats/challenges to public health. This is a dangerous trend and should be closely monitored.

SUBMITTER: Shen D 

PROVIDER: S-EPMC6395898 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Emergence of a Multidrug-Resistant Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strain with a Rare <i>bla</i><sub>CTX-M-24</sub>-Harboring Virulence Plasmid.

Shen Dingxia D   Ma Guannan G   Li Cuidan C   Jia Xinmiao X   Qin Chuan C   Yang Tingting T   Wang Lifeng L   Jiang Xiaoyuan X   Ding Nan N   Zhang Xiuli X   Yue Liya L   Yin Zhe Z   Zeng Lijun L   Zhao Yongliang Y   Zhou Dongsheng D   Chen Fei F  

Antimicrobial agents and chemotherapy 20190226 3

Here, we report a multidrug-resistant hypervirulent <i>Klebsiella pneumoniae</i> (MDR-HvKP) strain of sequence type 23 (ST23) with a rare hybrid plasmid harboring virulence genes and <i>bla</i><sub>CTX-M-24</sub>, and we analyze the genetic basis for relationship between genotypes and MDR-hypervirulence phenotypes. Further analysis indicates that the hybrid plasmid is formed by IS<i>903D</i>-mediated intermolecular transposition of the <i>bla</i><sub>CTX-M-24</sub> gene into the virulence plasmi  ...[more]

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