Emergence of a Multidrug-Resistant Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strain with a Rare bla CTX-M-24-Harboring Virulence Plasmid.
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ABSTRACT:
SUBMITTER: Shen D
PROVIDER: S-EPMC6395898 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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Emergence of a Multidrug-Resistant Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strain with a Rare <i>bla</i><sub>CTX-M-24</sub>-Harboring Virulence Plasmid.
Shen Dingxia D Ma Guannan G Li Cuidan C Jia Xinmiao X Qin Chuan C Yang Tingting T Wang Lifeng L Jiang Xiaoyuan X Ding Nan N Zhang Xiuli X Yue Liya L Yin Zhe Z Zeng Lijun L Zhao Yongliang Y Zhou Dongsheng D Chen Fei F
Antimicrobial agents and chemotherapy 20190226 3
Here, we report a multidrug-resistant hypervirulent <i>Klebsiella pneumoniae</i> (MDR-HvKP) strain of sequence type 23 (ST23) with a rare hybrid plasmid harboring virulence genes and <i>bla</i><sub>CTX-M-24</sub>, and we analyze the genetic basis for relationship between genotypes and MDR-hypervirulence phenotypes. Further analysis indicates that the hybrid plasmid is formed by IS<i>903D</i>-mediated intermolecular transposition of the <i>bla</i><sub>CTX-M-24</sub> gene into the virulence plasmi ...[more]
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