Ontology highlight
ABSTRACT:
SUBMITTER: Ismail N
PROVIDER: S-EPMC6395909 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ismail Nabila N Peters Remco P H RPH Ismail Nazir A NA Omar Shaheed V SV
Antimicrobial agents and chemotherapy 20190226 3
Six <i>in vitro</i> clofazimine-resistant spontaneous mutants obtained from a wild-type or pyrazinamide-resistant ATCC reference strain were selected to evaluate bedaquiline cross-resistance. The reverse was conducted for bedaquiline mutants. All clofazimine mutants harboring an <i>rv0678</i> mutation displayed phenotypic cross-resistance. We observed the same for <i>rv0678</i> bedaquiline mutants; however, <i>atpE</i> bedaquiline mutants showed no phenotypic cross-resistance. This confirms that ...[more]