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MiR-212 regulated by HIF-1? promotes the progression of pancreatic cancer.


ABSTRACT: MicroRNA-212 (miR-212) is dysregulated in numerous tissues and cancer types and serves a role in the progression of human cancer. However, the function and mechanism of miR-212 in the development of pancreatic ductal adenocarcinoma (PDAC) remain unknown, particularly in a hypoxic microenvironment. In the present study, miR-212 expression was observed to be significantly upregulated in PDAC tissues compared with normal tissues. Clinical data analysis indicated that miR-212 was positively associated with a large tumor size, Tumor-Node-Metastasis stage, lymph node metastasis and vessel invasion, and influenced the overall survival time. Notably, there was a positive association between the expression of hypoxia-inducible factor-1? (HIF-1?) and miR-212 in vivo and in vitro in hypoxic conditions. Mechanistically, HIF-1? bound directly to a hypoxia response element in the miR-212 promoter region and activated miR-212 expression in PDAC cells. Collectively, these results demonstrated that HIF-1? positively regulated miR-212 expression and resulted in PDAC progression.

SUBMITTER: Yue H 

PROVIDER: S-EPMC6396010 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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miR-212 regulated by HIF-1α promotes the progression of pancreatic cancer.

Yue Hui H   Liu Lin L   Song Zhenguo Z  

Experimental and therapeutic medicine 20190129 3


MicroRNA-212 (miR-212) is dysregulated in numerous tissues and cancer types and serves a role in the progression of human cancer. However, the function and mechanism of miR-212 in the development of pancreatic ductal adenocarcinoma (PDAC) remain unknown, particularly in a hypoxic microenvironment. In the present study, miR-212 expression was observed to be significantly upregulated in PDAC tissues compared with normal tissues. Clinical data analysis indicated that miR-212 was positively associat  ...[more]

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