YAP1 overexpression is associated with poor prognosis of breast cancer patients and induces breast cancer cell growth by inhibiting PTEN.
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ABSTRACT:
SUBMITTER: Guo L
PROVIDER: S-EPMC6396162 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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YAP1 overexpression is associated with poor prognosis of breast cancer patients and induces breast cancer cell growth by inhibiting PTEN.
Guo Liwen L Chen Yutang Y Luo Jun J Zheng Jiaping J Shao Guoliang G
FEBS open bio 20190214 3
YES-associated protein 1 (YAP1) plays a key role as a transcriptional coactivator in the Hippo tumor suppressor pathway. YAP1 is overexpressed in a variety of cancers and is considered to be encoded by a proto-oncogene. However, the role of YAP1 remains debatable, because both gain and loss of YAP1 expression have both been reported in breast cancer (BC). Here, we found that elevated expression of YAP1 mRNA in BC was negatively correlated with relapse-free, distant metastases-free and overall su ...[more]
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