Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC6396169 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhao Yu Y Ding Liya L Wang Dejie D Ye Zhenqing Z He Yundong Y Ma Linlin L Zhu Runzhi R Pan Yunqian Y Wu Qiang Q Pang Kun K Hou Xiaonan X Weroha Saravut J SJ Han Conghui C Coleman Roger R Coleman Ilsa I Karnes R Jeffery RJ Zhang Jun J Nelson Peter S PS Wang Liguo L Huang Haojie H
The EMBO journal 20190205 5
In light of the increasing number of identified cancer-driven gain-of-function (GOF) mutants of p53, it is important to define a common mechanism to systematically target several mutants, rather than developing strategies tailored to inhibit each mutant individually. Here, using RNA immunoprecipitation-sequencing (RIP-seq), we identified the Polycomb-group histone methyltransferase EZH2 as a p53 mRNA-binding protein. EZH2 bound to an internal ribosome entry site (IRES) in the 5'UTR of p53 mRNA a ...[more]