Trajectories of Alcohol Initiation and Use During Adolescence: The Role of Stress and Amygdala Reactivity.

ABSTRACT:

Objective

Early alcohol use initiation predicts onset of alcohol use disorders in adulthood. However, little is known about developmental trajectories of alcohol use initiation and their putative biological and environmental correlates.

Method

Adolescents (N = 330) with high or low familial loading for depression were assessed annually for up to 6 years. Data were collected assessing affective symptoms, alcohol use, and stress at each assessment. Adolescents also participated in a functional magnetic resonance imaging protocol that included measurement of threat-related amygdala and reward-related ventral striatum activity.

Results

Latent class analyses identified 2 trajectories of alcohol use initiation. Early initiators (n = 32) reported greater baseline alcohol use

SUBMITTER: Elsayed NM 

PROVIDER: S-EPMC6396321 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature