Ontology highlight
ABSTRACT:
SUBMITTER: Karasmanis EP
PROVIDER: S-EPMC6396981 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Karasmanis Eva P EP Phan Cat-Thi CT Angelis Dimitrios D Kesisova Ilona A IA Hoogenraad Casper C CC McKenney Richard J RJ Spiliotis Elias T ET
Developmental cell 20180701 2
Neuronal function requires axon-dendrite membrane polarity, which depends on sorting of membrane traffic during entry into axons. Due to a microtubule network of mixed polarity, dendrites receive vesicles from the cell body without apparent capacity for directional sorting. We found that, during entry into dendrites, axonally destined cargos move with a retrograde bias toward the cell body, while dendritically destined cargos are biased in the anterograde direction. A microtubule-associated sept ...[more]