Ontology highlight
ABSTRACT:
SUBMITTER: Leal LF
PROVIDER: S-EPMC6397232 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Leal Letícia Ferro LF de Paula Flávia Escremim FE De Marchi Pedro P de Souza Viana Luciano L Pinto Gustavo Dix Junqueira GDJ Carlos Carolina Dias CD Berardinelli Gustavo Noriz GN Miziara José Elias JE da Silva Carlos Maciel CM Silva Eduardo Caetano Albino ECA Pereira Rui R de Oliveira Marco Antonio MA Scapulatempo-Neto Cristovam C Reis Rui Manuel RM
Scientific reports 20190301 1
Lung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KRAS mutations in a large Brazilian series of lung adenocarcinoma together with patients' genetic ancestry, clinicopathological and sociodemographic characteristics. The mutational frequency of EGFR was ...[more]