Genome-wide DNA methylation profiles in Tibetan and Yorkshire pigs under high-altitude hypoxia.

ABSTRACT:

Background

Tibetan pigs, which inhabit the Tibetan Plateau, exhibit distinct phenotypic and physiological characteristics from those of lowland pigs and have adapted well to the extreme conditions at high altitude. However, the genetic and epigenetic mechanisms of hypoxic adaptation in animals remain unclear.

Methods

Whole-genome DNA methylation data were generated for heart tissues of Tibetan pigs grown in the highland (TH, n = 4) and lowland (TL, n = 4), as well as Yorkshire pigs grown in the highland (YH, n = 4) and lowland (YL, n = 4), using methylated DNA immunoprecipitation sequencing.

Results

We obtained 480 million reads and detected 280679, 287224, 259066, and 332078 methylation enrichment peaks in TH, YH, TL, and YL, respectively.

SUBMITTER: Zhang B 

PROVIDER: S-EPMC6397503 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature