Ontology highlight
ABSTRACT:
SUBMITTER: Ishigami I
PROVIDER: S-EPMC6397517 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Ishigami Izumi I Lewis-Ballester Ariel A Echelmeier Austin A Brehm Gerrit G Zatsepin Nadia A NA Grant Thomas D TD Coe Jesse D JD Lisova Stella S Nelson Garrett G Zhang Shangji S Dobson Zachary F ZF Boutet Sébastien S Sierra Raymond G RG Batyuk Alexander A Fromme Petra P Fromme Raimund R Spence John C H JCH Ros Alexandra A Yeh Syun-Ru SR Rousseau Denis L DL
Proceedings of the National Academy of Sciences of the United States of America 20190211 9
Cytochrome <i>c</i> oxidase (C<i>c</i>O) reduces dioxygen to water and harnesses the chemical energy to drive proton translocation across the inner mitochondrial membrane by an unresolved mechanism. By using time-resolved serial femtosecond crystallography, we identified a key oxygen intermediate of bovine C<i>c</i>O. It is assigned to the P<sub>R</sub>-intermediate, which is characterized by specific redox states of the metal centers and a distinct protein conformation. The heme <i>a</i><sub>3< ...[more]