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Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer.

ABSTRACT: BACKGROUND:The lethal-7 (let-7) family members and their targets are involved in the development and progression of tumors. Let-7-related polymorphisms have been reported to be associated with tumorigenesis and prognosis. In gastric cancer, however, the related studies are limited. AIM:To investigate the role of let-7-related microRNA polymorphisms in the tumorigenesis and prognosis of gastric cancer in a Chinese population. METHODS:A total of 898 gastric cancer patients and 992 tumor-free controls were recruited into this study from 2008 to 2013. Gastric cancer patients were followed periodically. Ten single nucleotide polymorphisms (SNPs) in the let-7 gene region or their target mRNAs were genotyped using the MassARRAY system and their associations with the risk for or overall survival of gastric cancer were analyzed. RESULTS:All the ten SNPs were in Hardy-Weinberg equilibrium. The C allele of the rs3811463 polymorphism in the 3'-untranslated region (UTR) of LIN28A was associated with a lower risk of gastric cancer [odds ratio (OR) = 0.74, 95% confidence interval (CI): 0.61-0.88, P = 0.001] after adjustment for age and Helicobacter pylori status. Seven hundred and thirty-five gastric cancer patients who had undergone radical tumorectomy were included in the survival analysis and their 5-year survival rate was 53.9% (95%CI: 50.1%-57.6%). The rs10889677 in the 3'-UTR of IL23R was corresponded to the prognosis of gastric cancer in a dose-response manner, in which the death risk increased by 25% [hazard ratio (HR) = 1.25, 95%CI: 1.04-1.45, P = 0.011] with each increase in the number of C alleles after controlling for other potential clinicopathological parameters. CONCLUSION:The let-7-related polymorphism rs3811463 in LIN28A is associated with the susceptibility to gastric cancer and the let-7-related polymorphism rs10889677 in IL23R is associated with the prognosis of gastric cancer.

SUBMITTER: Jia ZF

PROVIDER: S-EPMC6397727 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer.

Jia Zhi-Fang ZF Cao Dong-Hui DH Wu Yan-Hua YH Jin Mei-Shan MS Pan Yu-Chen YC Cao Xue-Yuan XY Jiang Jing J

World journal of gastroenterology 20190201 8

<h4>Background</h4>The lethal-7 (<i>let-7</i>) family members and their targets are involved in the development and progression of tumors. <i>Let-7</i>-related polymorphisms have been reported to be associated with tumorigenesis and prognosis. In gastric cancer, however, the related studies are limited.<h4>Aim</h4>To investigate the role of <i>let-7</i>-related microRNA polymorphisms in the tumorigenesis and prognosis of gastric cancer in a Chinese population.<h4>Methods</h4>A total of 898 gastr ...[more]

PMID: 30833806

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Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer.

Publications

Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer.

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