Quantitative assessment of outer retinal layers and ellipsoid zone mapping in hydroxychloroquine retinopathy.

ABSTRACT:

Background

To quantitatively assess outer retinal layers in eyes with hydroxychloroquine (HCQ) toxicity.

Methods

A retrospective case-control study was performed to identify eyes with HCQ retinopathy/toxicity at Cleveland Clinic. A clinical diagnosis of HCQ retinopathy was made based on clinical and imaging features including the presence of parafoveal ellipsoid zone (EZ) loss on spectral-domain optical coherence tomography (OCT) and visual field defects. All participants underwent macular cube scan using the Cirrus HD-OCT (Zeiss, Oberkochen, Germany). Quantitative assessment of outer nuclear layer (ONL)/Henle fibre layer complex (HFL) metrics and EZ mapping were performed with a novel software platform and compared with age-matched controls. HCQ toxicity group was divided i

SUBMITTER: Ugwuegbu O 

PROVIDER: S-EPMC6397800 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature