Ontology highlight
ABSTRACT:
SUBMITTER: Starr ML
PROVIDER: S-EPMC6398130 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Starr Matthew L ML Sparks Robert P RP Arango Andres S AS Hurst Logan R LR Zhao Zhiyu Z Lihan Muyun M Jenkins Jermaine L JL Tajkhorshid Emad E Fratti Rutilio A RA
The Journal of biological chemistry 20190107 9
Eukaryotic cell homeostasis requires transfer of cellular components among organelles and relies on membrane fusion catalyzed by SNARE proteins. Inactive SNARE bundles are reactivated by hexameric <i>N</i>-ethylmaleimide-sensitive factor, vesicle-fusing ATPase (Sec18/NSF)-driven disassembly that enables a new round of membrane fusion. We previously found that phosphatidic acid (PA) binds Sec18 and thereby sequesters it from SNAREs and that PA dephosphorylation dissociates Sec18 from the membrane ...[more]