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Benefits of annual chemotherapeutic control of schistosomiasis on the development of protective immunity.


ABSTRACT: BACKGROUND:Schistosomiasis is a devastating parasitic disease. The mainstay of schistosomiasis control is by praziquantel treatment. The study aimed to determine benefits of annual chemotherapy of schistosomiasis on development of protective immunity in school children in a selected endemic rural area in Zimbabwe. METHODS:Urine specimens from 212 school children (7-13?years) were collected and examined to determine prevalence, intensity and reinfection of S.haematobium at baseline, 6?weeks and 2?years following annual rounds of praziquantel treatment. Blood samples from the participants were assayed for total and S. haematobium (Sh13)-specific antibodies before and 2?years after annual rounds of treatment. RESULTS:Annual treatment reduced the prevalence of S. haematobium infection (p?

SUBMITTER: Chisango TJ 

PROVIDER: S-EPMC6398226 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Benefits of annual chemotherapeutic control of schistosomiasis on the development of protective immunity.

Chisango Tawanda J TJ   Ndlovu Bongiwe B   Vengesai Arthur A   Nhidza Agness Farai AF   Sibanda Edson P EP   Zhou Danai D   Mutapi Francisca F   Mduluza Takafira T  

BMC infectious diseases 20190304 1


<h4>Background</h4>Schistosomiasis is a devastating parasitic disease. The mainstay of schistosomiasis control is by praziquantel treatment. The study aimed to determine benefits of annual chemotherapy of schistosomiasis on development of protective immunity in school children in a selected endemic rural area in Zimbabwe.<h4>Methods</h4>Urine specimens from 212 school children (7-13 years) were collected and examined to determine prevalence, intensity and reinfection of S.haematobium at baseline  ...[more]

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