Repeat dose exposure of PM_2.5 triggers the disseminated intravascular coagulation (DIC) in SD rats.

ABSTRACT: Epidemiological evidence suggests that fine particulate matter (PM_2.5) in air pollution promotes the formation of deep venous thrombosis. However, no evidence is available on the effects of PM_2.5 lead to disseminated intravascular coagulation (DIC). For the first time, this study explored the effects of PM_2.5 on DIC via coagulation disorders in vivo. SD rats received intratracheal instillation of PM_2.5 once every three days for one month. Doppler ultrasound showed that the pulmonary valve (PV) and aortic valve (AV) peak flow were decreased after exposure to PM_2.5. Fibrin deposition and bleeding were observed in lung tissue and vascular endothelial injury was found after exposure to PM_2.5. Expression of thrombomodulin (TM) in

SUBMITTER: Liang S 

PROVIDER: S-EPMC6398278 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature